Colorado vs. Nebraska Prediction, Odds: Expert College Football 2024 Picks, Betting by Deion Sanders

Deion Sanders and the Colorado Buffaloes (1-0) hit the road in Week 2 to face longtime rival Nebraska (1-0) on Saturday in Lincoln, Nebraska. The Buffs won their season opener, defeating FCS powerhouse North Dakota State 31-26 thanks to standout performances from Heisman Trophy candidates Shedeur Sanders and Travis Hunter. The Huskers opened Year 2 of the Matt Rhule era with a dominant 40-7 win over UTEP. Heralded freshman quarterback Dylan Raiola had a strong performance in his collegiate debut for Nebraska. This will be the 73rd meeting between CU and Nebraska, with the Huskers leading the series 49-21-2.

Kickoff is at 7:30 p.m. ET at Memorial Stadium in Lincoln, Nebraska. The Huskers are a 6.5-point favorite in the latest Colorado vs. Nebraska odds, according to SportsLine consensus. The over/under for total points is 55.5. Before you make your Nebraska vs. Colorado picks, you need to check out SportsLine's Jimmie Kaylor's Week 2 college football predictions and betting tips.

Kaylor is an NFL, college football and DFS expert for SportsLine who has covered the NFL and college football for nearly a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and setting his betting picks. He has his finger on the pulse of the college football landscape and has made a lot of money over the past two years.

Kaylor broke college football records in 2023, scoring a whopping 57.9 units and compiling a record of 107-45-2. Anyone who followed his picks finished the season high.

Now Kaylor has tuned in to Colorado vs. Nebraska on Saturday and just announced his picks and predictions. You can head over to SportsLine now to see his picks. Here are the college football odds and college football betting odds for the spread, money line and over/under for Nebraska vs. Colorado:

• Colorado vs. Nebraska Spread: Nebraska -6.5
• Colorado vs. Nebraska over/under: 55.5 points
• Colorado vs. Nebraska – Line: Nebraska -242, Colorado +195
• Colorado vs. Nebraska picks: See picks at SportsLine

Why Colorado can cover

Dylan Raiola could prove to be the savior of Nebraska football, but Colorado has an undeniable advantage at the quarterback position in senior Shedeur Sanders. The 6-foot-2, 215-pound Sanders threw for 445 yards and four touchdowns in CU's season-opening win. Sanders led Colorado to a 36-14 victory over Nebraska in 2023.

Colorado also has a group of wide receivers that will test Nebraska's secondary. Two-way star Travis Hunter delivered a Heisman Trophy-caliber performance against North Dakota State, catching seven passes for 132 yards and three touchdowns and recording three tackles on defense. Jimmy Horn Jr., Will Sheppard and LaJohntay Wester round out the Buffs' receiver group. Horn caught seven passes for 198 yards and a touchdown against NDSU. Here's which team to pick.

Why Nebraska can cover

Nebraska has a clear advantage at the line of scrimmage in this matchup. Colorado has an entirely new offensive line and the Huskers have experience in their defensive front seven. If Nebraska can get a consistent pass rush on Sanders, it can help neutralize Colorado's speed at the wide receiver position.

Colorado's defense struggled for most of the game against North Dakota State. Nebraska rushed for 223 yards against UTEP and the Buffs struggled to stop the run in their season opener. Freshman quarterback Dylan Raiola looked confident in his first college start and his throwing technique will put a lot of pressure on Colorado's secondary. Here's which team to pick.

How to make your predictions for Nebraska vs. Colorado

Kaylor has analyzed Colorado vs. Nebraska from every angle and is leaning toward the over on the total score. He's also discovered a key X-factor that has him jumping to one side of the spread. He shares what it is and which side to bet on only at SportsLine.

So who will win Colorado over Nebraska on Saturday in Lincoln, and what crucial X-factor makes one side of the spread a must-win? Visit SportsLine now to see which side of the spread you should jump on, all from the expert who made $5,790 in profit on $100 college football bets in 2023, and find out.