Tennessee vs. Oklahoma odds, prediction, spread: 2024 College Football Week 4 picks from experts with 15-6 throw

The Tennessee Volunteers (No. 6, 3-0) will play their first true road game of the season when they face the Oklahoma Sooners (No. 15, 3-0) in an SEC opener on Saturday night. Tennessee defeated then-No. 24 NC State by 41 points two weeks ago in Charlotte before a resounding 71-0 victory over Kent State last week. Oklahoma is ending a four-game home series that began with wins over Temple, Houston and Tulane. This will be the first meeting between Tennessee and Oklahoma since Baker Mayfield led the Sooners to a 31-24 victory in Knoxville in 2015. Tennessee coach Josh Heupel led Oklahoma to the national title as quarterback in 2020 and was also with the team as an assistant coach from 2006-14.

Kickoff at Gaylord Family-Oklahoma Memorial Stadium in Norman is set for 7:30 p.m. ET. Tennessee is a 7-point favorite in the latest Oklahoma vs. Tennessee odds from SportsLine Consensus, although Oklahoma opens as a 4.5-point favorite in the projections. The over/under for total points scored is 57, which is 4.5 points less than the opener (61.5). Before you place your Tennessee vs. Oklahoma picks, be sure to read what SportsLine expert Emory Hunt has to say.

Hunt is the founder and CEO of Football Gameplan, which has provided analysis of all levels of football since 2007, and a former running back at Louisiana-Lafayette. He knows the game from a player's perspective.

Hunt's commitment to analyzing all levels of college and professional football helped him to a 93-78-5 (+777) record in all college football picks in 2023. He also has a record of 15-6 (+837) in his last 21 games against Tennessee. Anyone who has followed him is way up there.

Now Hunt has turned his attention to Oklahoma vs. Tennessee and just gave his picks and CFB predictions. You can head over to SportsLine now to see Hunt's picks. Here are some college football odds and betting lines for the spread, money line and over/under for Tennessee vs. Oklahoma:

• Tennessee vs. Oklahoma Spread: Tennessee -7
• Tennessee vs. Oklahoma over/under: 57 points
• Tennessee vs. Oklahoma Money Line: Tennessee -260, Oklahoma +208
• OU: The Sooners have won their last 10 home games 10-0
• TENN: The Vols have covered the spreads in four of their last five games
• Tennessee vs. Oklahoma Picks: See Picks at SportsLine

Why Oklahoma can cover

Oklahoma was a 4.5-point favorite in the previews for this game two weeks ago, and the Sooners have taken advantage in two of their first three games. They haven't been a one-touchdown underdog at home since 1998. It's an ideal schedule for the Sooners, as they're playing at home for the fourth straight year, while Tennessee is playing on the road for the second time in the last three weeks.

Sooners quarterback Jackson Arnold has thrown for 484 yards and seven touchdowns. He's also the team's leading runner with 159 yards and two touchdowns and is helped by an Oklahoma defense that limits opponents to fewer than 265 yards per game. The Sooners have also forced a nation-leading 10 turnovers and are on a 10-game home winning streak. See who to bet on at SportsLine.

Why Tennessee can cover

Tennessee is off to a perfect start this season, easily scoring points in all three blowout victories. The Vols are the nation's leading scorer at 61.0 points per game, with running back Dylan Sampson scoring nine touchdowns and averaging 119 rushing yards per game. Redshirt freshman quarterback Nico Iamaleava was able to rest the second half of all three games, but still threw for 698 yards and six touchdowns.

The Vols have arguably been just as impressive on defense, holding opponents to just 4.3 points and 160.7 yards per game. They face an Oklahoma offensive line that has already allowed 11 sacks and hasn't created many running lanes. The Sooners also have significantly more injury issues than a relatively healthy Tennessee team. See who to bet on at SportsLine.

How to make your picks for Oklahoma vs. Tennessee

Hunt has analyzed this matchup from every angle. He's found one crucial X-factor that will have him jumping to one side of the spread. See what it is at SportsLine.

Who will win Tennessee over Oklahoma and what crucial X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the spread to jump on Saturday, all from the expert who gave his college football picks last year and is 15-6 (+837) on his last 21 sides in Tennessee games.