Colorado vs. Baylor prediction, odds, line, spread: Expert picks for 2024 college football, top bets on Deion Sanders

Deion Sanders and the Colorado Buffaloes (2-1) will usher in a new era when they host the Baylor Bears at Folsom Field on Saturday. CU has returned to the Big 12 after 13 seasons in the Pac-12, and Saturday's game will be the program's first conference game since the move. The Buffs will look to build on their 28-9 victory over Colorado State in Week 3. Quarterback Shedeur Sanders and two-way star Travis Hunter were dominant in the win. Baylor is coming off an impressive 31-3 victory over Air Force last week. The Bears lead the nation in pass defense and have their sights set on returning to a bowl game in 2024 after finishing 2023 with a 3-9 record.

Kickoff in Boulder is set for 8 p.m. ET. The Buffaloes are 2-point favorites in the latest Colorado vs. Baylor odds, according to SportsLine consensus, and the over/under is set at 51.5. Before you place a bet on Baylor vs. Colorado, you need to check out SportsLine's Jimmie Kaylor's Week 4 college football predictions and betting tips.

Kaylor is an NFL, college football and DFS expert for SportsLine who has covered the NFL and college football for nearly a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and setting his betting picks. He has his finger on the pulse of the college football landscape and has made a lot of money over the past two years.

Kaylor broke college football records in 2023, scoring a whopping 57.9 units and compiling a record of 107-45-2. Anyone who followed his picks finished the season high.

Now, Kaylor has geared up for Saturday's Colorado vs. Baylor game and just announced his picks and predictions. You can head over to SportsLine now to see his picks. Here are the college football odds and college football betting odds for the spread, money line and over/under for Baylor vs. Colorado:

• Colorado vs. Baylor spread: Colorado -2
• Colorado vs. Baylor over/under: 51.5 points
• Colorado vs. Baylor Money Line: Colorado -126, Baylor +105
• Colorado vs. Baylor picks: See picks at SportsLine

Why Colorado can cover

Baylor is coming off a hard-fought win over Air Force. Given the Falcons' style of play, opposing teams often need two or more weeks to fully recover physically, which could bode well for the Buffs. Additionally, teams traveling to Colorado will have to deal with the altitude, which could prove beneficial in Saturday's late game.

The Buffs also have a huge X-factor in cornerback/wide receiver Travis Hunter. The former five-star recruit is one of the best players in the country at two very different positions and has the ability to single-handedly change the course of games. Hunter enters Saturday with 30 catches for 342 yards and five touchdowns on offense, as well as 11 tackles, two pass breakups and an interception on defense. Here's which team to pick.

Why Baylor can cover

In terms of overall matchups, Baylor has a lot going for it on Saturday. Colorado has attempted more passes than any other team in the country, and its offense relies heavily on getting the ball into the hands of Travis Hunter, Jimmy Horn Jr., LaJohntay Wester and Will Sheppard. The Bears currently have the best pass defense in the country, allowing just 75.7 yards per game through the air. Granted, one of Baylor's games was against Air Force, but the Bears may have the best defense the Buffs have played to date.

On offense, the Bears are physically strong and have a relentless running attack. Running backs Dawson Pendergrass (30 carries, 144 yards, one touchdown) and Richard Reese (35 carries, 140 yards, one touchdown) lead the way for Baylor. On a night that could be rainy in Boulder, the Bears' advantage in the running game could pay off. Here's which team to pick.

How to make your picks for Baylor vs. Colorado

Kaylor has analyzed Colorado vs. Colorado State from every angle and is leaning toward the under on the total score. He's also discovered a key X-factor that has him jumping to one side of the spread. He shares what it is and which side to bet on only with SportsLine.

So who will win Colorado over Baylor on Saturday at Folsom Field in Boulder, and what crucial X-factor makes one side of the spread a must-win? Visit SportsLine now to see which side of the spread you should jump on, all from the expert who made $5,790 in profit on $100 college football bets in 2023, and find out.