The true story behind the brilliant minds at NBC

Nearly 20 years after his breakout role in “Heroes,” Zachary Quinto returns to NBC as an eccentric world-class doctor in “Brilliant Minds.” The “Star Trek” and “American Horror Story” star plays Dr. Oliver Wolf, a neurologist living with a brain disorder – prosopagnosia, colloquially known as “face blindness” – who believes that “you can't treat a patient without understanding who they really are, and that sometimes the only treatment is to break the rules.”

But Dr. Oliver Wolf is not a figment of fiction, and his philosophies were not invented for the screen—his roots lie in the incredible true story of a legendary doctor. Here's what you need to know to find out what's true in “Brainy Minds.”

Is “Brilliant Minds” based on a true story?

Yes, but it does not strictly follow the information provided by the real Dr. Oliver.

Brilliant Minds is inspired by the life and works of the famous British physician, author and professor Dr. Oliver Sacks. However, case histories from his books are adapted as a case of the week for Dr. Wolf and his team, but also reinterpreted in a contemporary context and dramatized for television.

Who is Dr. Oliver Sacks – and what does he have in common with Dr. Oliver Wolf?

“The brain shapes us and is shaped by us – it makes us who we are.” – Dr. Oliver Sacks

Oliver Sacks was a renowned neurologist. He was born in 1933 and died in 2015 after a pioneering career in which he researched countless neurological disorders, including epilepsy, Parkinson's, autism, dementia and schizophrenia. He also became an essayist and bestselling author and incorporated his findings into a series of books.

During the Television Critics Association press tour in summer 2024, Quinto described Dr. Sacks as his “north star” in his approach to the role of Dr. Wolf.

“He was an incredible, complex, inspiring and influential doctor and human being,” the actor explained. “So for me, it's this very special alchemy of playing a character who is inspired by a real person, but I'm not tied to the time or the behavior of that person in real life. I can use all the rich diversity of who Oliver Sacks was and influence the creation of Oliver Wolf, but Oliver Wolf exists in his own world.”

Where does the name Dr. Wolf come from? Well, that one too comes from Oliver Sacks, whose middle name was Wolf. Among other details included in the show, the real Sacks was both a motorcyclist and a swimmer in the rivers of New York.

As portrayed in the series, Sacks was also gay, but did not come out until much later in life – just months before his death in his memoir, On the Move: A Life.

“Playing an openly gay character on a primetime show is an incredible honor for me. I am deeply grateful for this experience, to be able to tell these stories and use the life of Oliver Sacks as a starting point for these stories,” Quinto said during the TCA panel.

“Oliver Sacks was someone who was very much shaped by the times in which he came of age and the societal constraints that made it impossible for people to fully be who they were,” Quinto continued. “So he didn't come out until much later in life. He eventually met a partner and had a really happy relationship until the end of his life. But to play a character who embraces that aspect of himself in the modern world in a way that is vital, contemporary and forward-looking is really something special.”

His sexuality and his relationship with his partner Bill Hayes were documented in Ric Burns' documentary His Own Life, which was filmed over a period of several days toward the end of Sacks' life.

Does he really suffer from face blindness?

In the series, Dr. Oliver Wolf doesn't just research brain disorders, he has lived with one his entire life: prosopagnosia, or “face blindness” as it is more commonly called. It's a real condition, and a relatively common one at that – and yes, Dr. Oliver Sacks had it too.

Which books is “Brilliant Minds” based on?

Executive producer Michael Grassi told the TCA that he was sent two books when the project was pitched: The Man Who Mistook His Wife for a Hat (1985) and An Anthropologist on Mars (1995).

“We take so many incredible cases from those books and then put them in the present day where we're having conversations that feel somehow urgent and pressing with Oliver Sacks' incredible material,” Grassi said, stressing that the source material is “incredibly insightful for what we're doing on this show.”

The doctor's books have been adapted into films before, first in Penny Marshall's 1990 film Awakenings, in which Robin Williams played a role inspired by Dr. Sacks and Robert De Niro was his patient. Williams and Sacks famously became friends after the popular actor played him, with Sacks describing them as “complementary beings.”

The 1999 romantic drama “At First Sight,” starring Val Kilmer and Mira Sorvino, was also adapted based on his writings.

“Brilliant Minds” airs Mondays at 10 p.m. ET/PT on NBC.