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The Detroit Lions are back in prime time on Monday Night Football against the undefeated Seattle Seahawks.

The Lions (2-1) are hosting their second prime-time game at Ford Field in the opening month of the 2024 NFL season, entering last Sunday's game with a road win over the Arizona Cardinals. This is the fourth straight season these two teams have met, with Seattle boasting a 3-0 record against Dan Campbell's teams.

Both teams come into the game with big defensive gaps that need to be filled. The Lions are without safety Brian Branch, who was demoted Saturday due to illness, in addition to losing linebacker Derrick Barnes, defensive end Marcus Davenport and safety Ifeatu Melifonwu to injured reserve. They will also be without their All-Pro center Frank Ragnow (torn pectoral muscle). Seattle will lose four key members of the top seven: Edge Boye Mafe, defensive end Leonard Williams, first-round rookie defensive tackle Byron Murphy and Edge Uchenna Nwosu.