Impact of SARS-CoV-2 viral load on restrictive spirometry patterns in middle-aged individuals who recovered easily from COVID-19: a six-month prospective study | BMC infectious diseases

Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LF. The COVID-19 Trinity: Immunity, Inflammation and Intervention. Nat Rev Immunol. 2020;20:363–74.

Article CAS PubMed PubMed Central Google Scholar

World Health Organization COVID-19 report. 2023. https://covid19.who.int/

Rando R HM, MacLean AL, Lee AJ, Lordan, Ray S, Bansal V, et al. Pathogenesis, symptomatology and transmission of SARS-CoV-2 through analysis of viral genomics and structure. MSystems. 2021;6:msystems101128–00095.

Wu D, Wu T, Liu Q, Yang Z. The SARS-CoV-2 outbreak: What we know. Int J Infect Dis. 2020;94:44–8.

Article CAS PubMed PubMed Central Google Scholar

Wanjari M, Late S, Sharma R, Munjewar P. Long-term pulmonary and extrapulmonary consequences of COVID-19: a comprehensive review of current evidence and future perspectives. Narra J. 2023;3:e156–e.

PubMed PubMed Central Google Scholar

Van Heerden J. The influence of SARS-CoV-2 on respiratory function. Stellenbosch: Stellenbosch University; 2023.

Google Scholar

De Juana C, Herrera S, Ponce S, Calvache S, Dahmazi L, Vitale R, et al. Health-related quality of life and radiological and functional lung changes of patients with COVID-19 pneumonia at 3 and 10 months after discharge. BMC Pulm Med. 2023;23:231.

Article PubMed PubMed Central Google Scholar

Jabbar AS, Mohammed RN, Ibrahim NK. Impact of COVID-19 infection on pulmonary function tests in patients 6-8 weeks after recovery. Int Med J 2021;28:5341–51.

Google Scholar

Hastie E, Amogan H, Looney D, Mehta SR. Association between SARS-CoV-2 viral load and patient symptoms and clinical outcomes using digital droplet PCR. Viruses. 2023;15:446.

Article CAS PubMed PubMed Central Google Scholar

Lawrence R, Singh RB, Prakash AK. Pulmonary dysfunction in patients recovering from Covid-19 pneumonia in a tertiary care hospital in India. Lungs India. 2023;40:248–52.

Article PubMed PubMed Central Google Scholar

Gandhi RT, Lynch JB, Del Rio C. Mild or moderate Covid-19. N Engl J Med 2020;383:1757–66.

Article CAS PubMed Google Scholar

Stanojevic S, Kaminsky DA, Miller MR, Thompson B, Aliverti A, Barjaktarevic I et al. ERS/ATS technical standard on interpretation strategies for routine pulmonary function tests. Eur Respir J 2022, 60.

Birman D. Studying the effects of Covid-19 on various organs of the body. Eurasian J Chem Med Petroleum Res. 2023;2:24–36.

Google Scholar

Toufen C, Pego-Fernandes PM. COVID-19: long-term consequences for the respiratory system. SciELO Brazil; 2021. pp. 421–3.

Patil S, Narkar S, Dahiphale J, Raka V, Choudhari S, Gondhali G. Long COVID symptoms, pathophysiology and possible mechanisms: We are still learning! World J Adv Pharm Med Res. 2023;4:053–65.

Article Google Scholar

Buonsenso D, Piazza M, Boner AL, Bellanti JA, editors. Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome. allergy and asthma procedures; 2022: OceanSide releases.

Dutey-Magni PF, Williams H, Jhass A, Rait G, Lorencatto F, Hemingway H, et al. COVID-19 infection and related mortality in UK nursing homes: cohort study with active surveillance and electronic records (March–June 2020). Age aging. 2021;50:1019–28.

Article PubMed PubMed Central Google Scholar

Huang L, Li X, Gu X, Zhang H, Ren L, Guo L, et al. Health outcomes in humans 2 years after surviving hospitalization with COVID-19: a longitudinal cohort study. Lancet Respiratory Med 2022;10:863–76.

Article CAS Google Scholar

Augustin M, Schommers P, Stecher M, Dewald F, Gieselmann L, Gruell H et al. Post-COVID syndrome in non-hospitalized patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Health–Europe 2021, 6.

Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y et al. Characterization of long-COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine 2021, 38.

Carfì A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324:603–5.

Article PubMed PubMed Central Google Scholar

McCracken IR, Saginc G, He L, Huseynov A, Daniels A, Fletcher S, et al. Lack of evidence for angiotensin-converting enzyme 2 expression and replicative infection by SARS-CoV-2 in human endothelial cells. Traffic. 2021;143:865–8.

Article CAS PubMed PubMed Central Google Scholar

Mostafa Y, Khalil MM, Hegazy SN, Daif MS. The result of pulmonary function tests and high-resolution chest computed tomography in confirmed cases of coronavirus disease 2019 after 3 months of recovery. Egypt J breast dis-tuberculosis. 2023;72:46–57.

Article Google Scholar

Cherrez-Ojeda I, Sanchez-Angarita E, Vanegas E, Bajaña MJF, Robles-Velasco K, Osorio MF, et al. Lung examination of post-COVID-19 patients: an Ecuadorian experience. J Community Hosp Intern Med Perspective. 2022;12:30.

Article PubMed PubMed Central Google Scholar

Navarro AO, Cervantes-Bojalil J, Quevedo OJC, Martínez AA, Hernández-Jiménez CA, Álvarez EP, et al. Reduced quality of life and spirometric changes even after mild to moderate COVID-19 disease. Respir Med. 2021;181:106391.

Article Google Scholar

Cortes-Telles A, Figueroa-Hurtado E, Ortiz-Farias DL, Zavorsky GS. Clinical predictors of lung function in patients recovering from mild COVID-19 disease. BMC Pulm Med. 2022;22:294.

Article CAS PubMed PubMed Central Google Scholar

Sui Z, Dai X, Lu Q, Zhang Y, Huang M, Li S, et al. Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection. Signal transduction target therapy. 2021;6:181.

Article CAS Google Scholar

Zsichla L, Müller V. Risk factors for severe COVID-19: a review of host, viral and environmental factors. Viruses. 2023;15:175.

Article CAS PubMed PubMed Central Google Scholar

Ra SH, Lim JS, Kim Gu, Kim MJ, Jung J, Kim SH. Upper respiratory tract viral load in asymptomatic individuals and mildly symptomatic patients with SARS-CoV-2 infection. Thorax. 2021;76:61–3.

Article PubMed Google Scholar

Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, et al. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nat Commun. 2020;11:5493.

Article CAS PubMed PubMed Central Google Scholar

Francistiová L, Klepe A, Curley G, Gulya K, Dinnyés A, Filkor K. Cellular and molecular effects of SARS-CoV-2 linking lung infections to the brain. Frontimmunol. 2021;12:730088.

Article PubMed PubMed Central Google Scholar