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Indianapolis Colts vs. Jacksonville Jaguars picks, NFL Week 5 odds

The Indianapolis Colts and Jacksonville Jaguars play on Sunday, October 6th at EverBank Stadium in a game on the NFL Week 5 schedule.

Which team will win the NFL game in Week 5?

Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, streaming at 10 a.m. MST on CBS (stream with FUBO free trial).

The Jaguars are a 2.5-point favorite over the Colts in the NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook.

Jacksonville is -145 on the money line while Indianapolis is +120.

The over/under (overall score) is set at 46 points.

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Watch Colts at Jaguars Live with FUBO (Free Trial)

Jeremy Cluff writes: “The Jaguars are favorites in this game at home. We believe they will win a game at some point, it might as well come in Week 5.”

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Bill Speros writes: “The Mac Jones clock continues. Just like the Doug Pederson watch.”

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The site's formula predicts the Colts will win the Week 5 NFL game against the Jaguars.

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Will Trevor Lawrence and the Jacksonville Jaguars beat the Indianapolis Colts on Sunday? NFL Week 5 picks, predictions and odds influence the game.

ESPN: The Colts have a 50.4% chance of beating the Jaguars on Sunday

The website gives the Jaguars a 49.2% chance of winning the NFL game in Week 5, with the remaining percentage being a tie.

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Dimers: Jaguars 25, Colts 23

It states: “After extensive simulations, our model gives the Colts a 41% probability of victory, while the Jaguars have a 59% probability of victory.”

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Reach Jeremy Cluff at [email protected]. Follow him on X, formerly Twitter @Jeremy_Cluff.

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BetMGM is the premier destination for sports betting odds all year round.

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