Jets vs. 49ers prediction, odds, line, spread, time: Monday Night Football tips from the model with 181-129 throw

Week 1 of the 2024 NFL season concludes with Monday Night Football between the New York Jets and the San Francisco 49ers. Both teams have Super Bowl aspirations and have played each other 14 times in history. The 49ers lead the all-time series 11-3, including a 4-2 home win. The Jets lost 31-13 to San Francisco in their last meeting at MetLife Stadium in 2020.

Kickoff at Levi's Stadium in Santa Clara, Calif. is scheduled for 8:15 p.m. ET. San Francisco is a 3.5-point favorite in the latest Jets vs. 49ers odds, according to SportsLine Consensus, while the over/under limit for total points is 43. Before you decide on a 49ers vs. Jets bet, be sure to check out the NFL predictions and betting tips from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, has gained well over $7,000 in top-rated NFL picks for $100 players since its launch. The model enters Week 1 of the 2024 NFL season on an incredible 181-129 run in top-rated NFL picks dating back to the 2017 season. It's also on a 35-21 run in top-rated NFL picks since Week 7 2022.

The model has been in the top 10 in pure NFL picks on NFLPickWatch four of the last six years and beat more than 94% of CBS Sports Football Pick'em four times during that time. Anyone who has been following it ranks way up there.

The model has now simulated Jets vs. 49ers 10,000 times and just announced its coveted NFL picks and predictions. You can head over to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, money line and over/under for betting on 49ers vs. Jets:

• Jets vs. 49ers Spread: San Francisco -3.5
• Jets vs. 49ers over/under: 43 points
• Jets vs. 49ers Money Line: 49ers -204, Jets +169
• SF: The 49ers have reached the 1H moneyline in 16 of their last 22 games
• NYJ: The Jets have been under in the fourth quarter in 11 of their last 17 games.
• Jets vs. 49ers Picks: See Picks at SportsLine

Why the 49ers can cover

The San Francisco 49ers are a top team in the NFL and want to continue to expand their dominance. Head coach Kyle Shanahan is one of the best playmakers in the league. Last season, the 49ers were second in the NFL in total offense (398.4), fourth in passing offense (257.9) and third in running offense (140.5).

This unit is loaded with playmakers, but running back Christian McCaffrey tops the list. The 28-year-old is a dual threat out of the backfield for the 49ers. He has hands like a wide receiver but runs the ball with force. Last season, he was second in the NFL in runs (272), fourth in rushing touchdowns (14) and first in rushing yards (1,459). He has 15 games in the regular season and postseason with at least 100 total scrimmage yards. See who to bet on at SportsLine.

Why the Jets can cover

The New York Jets added Tyron Smith, Morgan Moses and John Simpson to the offensive line this offseason to protect quarterback Aaron Rodgers and running back Breece Hall. The Iowa State product is an explosive playmaker with the ball in his hands. He can easily outrun defenders but has reliable hands as a pass catcher. In 2023, Hall finished the season with 994 rushing yards, 591 receiving yards and nine total touchdowns.

Tight end Tyler Conklin is another key player on offense. Conklin does a strong job attacking the gaps and will be a safety for Rodgers. The Central Michigan product caught 61 balls last year for a career-high 621 yards and 10.2 yards per pass. He had six games last season that received 50+ yards. See who to bet on at SportsLine.

How to make your predictions for the Jets vs. 49ers game

SportsLine's model is leaning towards the under-total, predicting the teams to combine for 43 points. The model also says one side of the spread will win in over 60% of simulations. Head to SportsLine to see NFL picks.

So who will win on Monday Night Football between the 49ers and Jets, and which side of the spread will win over 60% of the time? Visit SportsLine now to see which side of the 49ers-Jets spread you should bet on, all with the model that has returned well over $7,000 in top-rated NFL picks, and find out.