Packers vs. Colts prediction, odds, spread, line, time: 2024 NFL picks, Week 2 best bets from proven model

The Indianapolis Colts (0-1) will look to score their first win of the season when they face the Green Bay Packers (0-1) at Lambeau Field. In Week 1, the Colts fell short against the Houston Texans, losing 29-27 to their AFC South rivals. The Packers will also look to score their first win of the season after losing 34-29 to the Philadelphia Eagles in the NFL Brazil Game. Jordan Love (knee) is questionable for Green Bay.

Kickoff at Lambeau Field in Green Bay, Wisconsin, is scheduled for 1 p.m. ET. Indianapolis is favored by 2.5 points in the latest Packers vs. Colts odds from SportsLine Consensus, and the over/under is set at 40.5 points. Before you make a Colts vs. Packers bet, check out the NFL predictions and betting tips from SportsLine's proven computer simulation model.

The model, which simulates every NFL game 10,000 times, has gained well over $7,000 in top-rated NFL picks for $100 players since its inception. The model enters Week 2 of the 2024 NFL season with an incredible 184-130 run in top-rated NFL picks dating back to the 2017 season. It also has a 38-22 run in top-rated NFL picks since Week 7 2022.

The model has been in the top 10 in pure NFL picks on NFLPickWatch four of the last six years and beat more than 94% of CBS Sports Football Pick'em four times during that time. Anyone who has been following it ranks way up there.

The model has focused on Packers vs. Colts and just set its picks and predictions for NFL Week 2. You can head over to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for the spread, money line and over/under:

• Packers vs. Colts spread: Colts -2.5
• Packers vs. Colts over/under: 40.5 points
• Packers vs Colts Moneyline: Colts -141, Packers +120
• Packers vs. Colts Picks: See Picks at SportsLine

Why the Colts can cover

Colts quarterback Anthony Richardson has a skill set that will make things incredibly difficult for opposing defensive coordinators. The two-year pro from Florida is a true dual-threat quarterback who has one of the strongest arms in the league. In Week 1, Richardson completed 9 of 19 passes for 212 yards, two touchdowns and an interception. He also led the Colts in rushing with 56 yards and a touchdown on six carries.

The Colts also have a game-winning running back in Jonathan Taylor. The former Wisconsin star led the NFL in rushing in 2021 and is a true three-down running back. With Indianapolis' offensive line still one of the better groups in the league, Taylor could have a big day against a Green Bay defense that allowed Saquon Barkley to 109 yards and two touchdowns in Week 1. Here's which team to pick.

Why the Packers can cover

The Packers will likely be without Love, which is obviously a huge blow to the team's offense. Malik Willis will likely start in his place, and although he is still considered inexperienced, he already has three NFL starts in his career. Willis was drafted in the third round by Liberty in 2022.

The Packers have plenty of offensive talent that should make things easier for Willis on Sunday. Second-year pro Jayden Reed was outstanding in Green Bay's season opener. The former Michigan State wide receiver caught four passes for 138 yards and a touchdown and also scored a 33-yard rushing touchdown. Here's which team to pick.

How to make your predictions for the Packers vs. Colts game

The model has simulated Packers vs. Colts 10,000 times and the results are in. The model is trending ahead and has also generated a point spread pick that is accurate in well over 50% of simulations. You can only see the model's picks at SportsLine.

So who will win Colts vs. Packers in Week 2, and which side of the spread will win over 50% of the time? Visit SportsLine now to see which side of the Colts vs. Packers spread you should back and find out. All using the model that has returned well over $7,000 in top-rated NFL picks.