Injuries are piling up at the 49ers: Deebo Samuel is expected to be out for several weeks after straining his calf in the game against the Vikings

The San Francisco 49ers are dealing with another notable injury. The 49ers, who recently placed All-Pro running back Christian McCaffrey on the injured list, will also be without receiver Deebo Samuel for a few weeks after he suffered a calf strain in Sunday's loss to the Vikings, head coach Kyle Shanahan said Monday.

Samuel will likely miss at least one of the 49ers' upcoming games against a division rival. The 49ers will travel to the Rams (another NFC West team) in Week 3 before returning home to face the Patriots in Week 4. They will host division rival Arizona in Week 5 before traveling to their NFC West opponent Seattle in Week 6.

Samuel caught 8 of 10 passes for 110 yards in Sunday's 23-17 loss to the Vikings that dropped San Francisco to 1-1 after two games. He caught 5 of 9 passes for 54 yards and also ran for 23 yards and a score in the 49ers' season-opening win over the New York Jets.

Samuel's absence will certainly be a big problem for the 49ers. A former All-Pro, Samuel is one of the most versatile players in the NFL. Last year, Samuel missed two games due to injury, but caught seven touchdowns and ran for five more while leading the 49ers to their second consecutive NFC West division title.

However, if there is an offense capable of replacing key players, it is San Francisco's. Jordan Mason has filled in for McCaffrey superbly, rushing for 147 and 100 yards in his first two starts when McCaffrey was out, respectively. With Samuel out, the onus falls on Brandon Aiyuk to fill the void after he caught just 6 of 10 passes targeted in the 49ers' first two games.

The 49ers' offense also includes veteran wideout Jauan Jennings and longtime Pro Bowl tight end George Kittle. San Francisco is also monitoring the progress of first-round pick Ricky Pearsall, who is back on the road after being shot in the chest during an attempted robbery on Aug. 31.