Anthony Joshua vs. Daniel Dubois odds, line: September 21 fight tips, predictions from the boxing expert with a record of 54-13

Two of the world's best heavyweights will clash at London's Wembley Stadium on Saturday when 34-year-old challenger Anthony Joshua faces 27-year-old IBF heavyweight champion Daniel Dubois in a scheduled 12-round bout. Action is expected to begin around 11 a.m. ET. In his last fight last June, Dubois earned an eighth-round TKO victory over Filip Hrgovic to win the vacant interim heavyweight title. Joshua was also impressive in his last fight last March, knocking out Francis Ngannou in the second round of a scheduled 10-round bout. Dubois currently has a 95% KO win rate, while Joshua enters as the WBO's No. 1-ranked challenger.

Joshua is a -480 favorite (risk $480 to win $100) while Dubois comes back at +360 in the latest Daniel Dubois vs. Anthony Joshua odds. The over/under odds for the total rounds are 7.5. Before placing an Anthony Joshua vs. Daniel Dubois bet, be sure to check out the boxing predictions from SportsLine's Peter Kahn.

Kahn is a true boxing insider who always has his finger on the pulse of what is happening inside and outside the ring. He has trained numerous world champions and currently manages 20 fighters through his company Fight Game Advisors. Kahn won the Boxing Writers Association of America's Cus D'Amato Manager of the Year award in 2022 and was inducted into the Florida Boxing Hall of Fame in 2023.

Kahn is uncanny when it comes to picking fights. He's an astonishing 54-13 on his last 67 SportsLine boxing match picks, earning bettors over $4,000 in profit for every $100 he's made. Among his notable accomplishments is advising SportsLine members to bet on underdog Ryan Garcia (+500) against previously unbeaten super lightweight champion Devin Haney (-700) in their blockbuster fight in April. Anyone who's been following Kahn's boxing picks is way up there.

Now, Kahn has studied the Daniel Dubois vs. Anthony Joshua fight from every angle and revealed his top picks and best bets. You can see Kahn's boxing picks only at SportsLine.

Why you should support Joshua

Joshua is on a roll and hasn't been beaten since losing by split decision to Oleksandr Usyk for the WBA (Super), IBF, WBO, IBO and vacant The Ring heavyweight titles in August 2022. It was his second consecutive loss to Usyk, who won by unanimous decision in September 2021 to win all four heavyweight belts. Joshua began his professional career in October 2013 when he recorded a TKO victory over Emanuele Leo in the first round of their fight.

Joshua has dominated ever since. He has a record of 28-3 with 25 knockouts in 31 career fights. He is a two-time former unified heavyweight world champion, holding the WBA (Super), IBF and WBO titles twice between 2016 and 2021. He is also a former Olympic super heavyweight champion at the 2012 London Games. Here's which fighter you should bet on.

Why you should support Dubois

Dubois was also impressive. The 27-year-old started his career at full steam, winning his first 15 career fights, 14 of them by knockout. All but one of his victories were by knockout. His only two losses were also by knockout and came in world championship fights. After his last loss to Usyk in August 2023, he rebounded well and scored a TKO victory over Jarrell Miller at 2:52 of the 10th round in December 2023.

Dubois began his professional career in April 2017 when he defeated Marcus Kelly by knockout in just 35 seconds. He then made five consecutive first or second round knockouts. He won his first boxing title in July 2017 when he knocked out Mauricio Barragan in the second round to win the vacant WBC youth heavyweight title. As an amateur, he became a five-time national junior and British champion. Here's which fighter you should choose.

How to Make Your Dubois vs. Jones Picks

Kahn is trending over in the totals and has two strong top bets, including a moneyline winner and a prop pick. He only reveals who to bet on at SportsLine.

Who will win Daniel Dubois vs. Anthony Joshua and how exactly will the fight end? Visit SportsLine now for detailed picks and analysis from the unparalleled expert who has won more than $4,000 in the last 67 picks on $100 bets and find out.