2024 College Football Tips, Week 4 Odds, Lines, Bets from Proven Experts: This 3-Leg Parlay Brings 6-1

After easy wins over Akron and Western Michigan to start the season, the Ohio State Buckeyes are ranked No. 3 in the AP Top 25 heading into a Week 3 game against Marshall. With a Big Ten opener against Michigan State looming, Ryan Day hopes to keep his College Football Playoff contender focused for a Marshall team that has been bowl eligible the last three seasons under Charles Huff. According to the latest Week 4 college football odds via SportsLine Consensus, the Buckeyes are 39.5-point favorites at home against the Thundering Herd.

Meanwhile, rival Michigan faces a much tougher task on Saturday, as the No. 18 Wolverines host the No. 11 USC Trojans in a Big Ten clash on CBS at 3:30 p.m. ET. USC is the favorite for its first Big Ten clash by 4.5 points in the Week 4 college football odds. Before you decide on a Week 4 college football tip, be sure to check out Thomas Casale of the College Football Experts' Week 4 top picks, predictions and best bets.

A frequent guest on national radio and television shows discussing college sports, Casale has been betting — and winning — for more than 30 years. Over the last two college football seasons, Casale is 122-92-5 (57%) overall in his college football picks and 26-8 (76.4%) in bowl games — all publicly documented. Anyone who has followed him ranks high.

Now he's turned his attention to Week 4 college football odds and is sharing his three best bets at SportsLine. If you put them together, you could get a return of about 6:1. Get his best college football picks at SportsLine.

Top college football predictions for week 4

One of Casale's top picks for college football Season 4: He's backing LSU (-21.5) against UCLA on Saturday at 3:30 p.m. ET. Brian Kelly's seat looked warm after falling 17-0 to South Carolina last week and it might still be warm, but the Tigers were able to fight back to earn a 36-33 SEC road win last week and their College Football Playoff hopes are still very much alive entering Week 4.

The Tigers are ranked 16th in the AP Top 25 and LSU quarterback Garrett Nussmeier leads the SEC with 10 touchdown passes in his first three games. Meanwhile, UCLA was just crushed 42-13 at home in its Big Ten opener against Indiana. Hoosiers QB Kurtis Rourke completed 75.8% of his passes for 307 yards and four touchdowns in that win.

The Bruins will have a tough time contending with Nussmeier and wide receiver Kyren Lacy, who looks like the latest addition to a long line of great LSU receivers. Lacy has already caught five touchdowns this season and Casale expects a breakout performance for LSU on offense to make up the sizable gap at home. See what other picks Casale likes at SportsLine.

How to make your college football picks for Week 4

Casale also found two other college football picks he likes, including backing an overlooked team that “excels in the underdog role.” You can only see his picks at SportsLine.

What are the best bets for Week 4 of college football and which underdog should you bet on? Visit SportsLine now to see Thomas Casales' best college football bets, all from a proven college football handicapper who has gone 26-8 in bowl games over the past two seasons, and find out.