Giants vs. Cowboys odds, prediction, time, spread: Thursday Night Football picks from NFL model with 42-22 run

The Dallas Cowboys will look to continue their dominance over the New York Giants when they meet in the NFC East showdown on Thursday Night Football. Dallas posted 40-0 and 49-17 victories over New York a year ago and has rattled off six straight wins in that series. The Cowboys (1-2), who have won the NFC East in two of the last three seasons, will look to end a two-game losing streak. The Giants (1-2), who beat Cleveland 21-15 on Sunday, last beat Dallas at home in 2020, a 23-19 decision.

Kickoff at MetLife Stadium in East Rutherford, New Jersey is scheduled for 8:15 p.m. ET. The Cowboys are the favorites by 5.5 points in the latest Giants vs. Cowboys odds, while the over/under for total points is 45.5. Before you make a Cowboys vs. Giants pick, be sure to check out the NFL predictions and betting tips from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, has gained well over $7,000 on top-rated NFL picks since its launch for $100 players. The model enters Week 4 of the 2024 NFL season with an incredible 188-130 run on top-rated NFL picks dating back to the 2017 season. Since Week 7 of 2022, the record for the highest-rated NFL picks is also 42-22.

The model also ranked in the top 10 in straight NFL picks on NFLPickWatch over the past six years, beating more than 94% of CBS Sports' football pick'em players four times during that period. Anyone who has followed it is way up there.

Now the model has its sights set on Cowboys vs. Giants and has just set its picks and NFL predictions. You can now head over to SportsLine to see the model's picks. Here are several NFL odds and NFL betting lines for the spread, moneyline and over/under for Giants vs. Cowboys:

• Spread Giants vs. Cowboys: Dallas -5.5
• Giants vs. Cowboys over/under: 45.5 points
• Giants vs. Cowboys money line: Dallas -261, New York Giants +213
• DAL: Cowboys are 5-5 since the start of 2023
• NYG: Giants are 4-5 at MetLife Stadium since the start of last season
• Giants vs. Cowboys picks: See picks at SportsLine

Why you should support the Cowboys

Quarterback Dak Prescott has dominated the Giants throughout his career. In 13 career starts against New York, Prescott has a 101.6 rating and completed 279 of 436 passes (64%) for 3,433 yards (264.1 per game) and 25 touchdowns with six interceptions. He has completed 74 of 122 passes (60.7%) for 851 yards and four touchdowns this season. He was intercepted twice and has a rating of 85.8.

Fifth-year veteran wide receiver CeeDee Lamb has also played well against New York in his career. In six games against the Giants, he had 38 receptions for 529 yards (13.9 average) and two touchdowns. One of those touchdowns came last year in the November 12th meeting in Dallas. In that game, he caught 11 passes for 151 yards (13.7 average). See which team you should choose here.

Why you should support the Giants

New York has a one-two punch at wide receiver. Rookie Malik Nabers leads the team with 23 receptions for 271 yards (11.8 average) and three touchdowns. He also has six explosive plays of 20 or more yards, including a long play of 28 yards. He has 127 yards after catch with 14 first-down conversions.

Also leading the receiving corps is third-year veteran Wan'Dale Robinson. The former second-round pick has 15 receptions for 123 yards (8.2 average) and one touchdown. He has a long reception of 20 yards with 63 yards after the catch and eight first-down conversions. In Sunday's win at Cleveland, Robinson caught seven passes for 61 yards. See which team you should choose here.

How to make Cowboys vs. Giants picks

SportsLine's model is below the overall result, predicting 44 points. It also says that one side of the spread has all of the value. You can get the NFL model selection only at SportsLine.

So who will win the Cowboys vs. Giants on Thursday Night Football and which side of the spread has the most value? Head to SportsLine now to see which side of the Cowboys vs. Giants you should fall on, all from the advanced model that's up well over $7,000 on its NFL picks, and find out.