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Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank | BMC Medicine

  • Collaborators GBDDF. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105–25.

    Google Scholar 

  • Wimo A, Seeher K, Cataldi R, Cyhlarova E, Dielemann JL, Frisell O, et al. The worldwide costs of dementia in 2019. Alzheimers Dement. 2023;19(7):2865–73.

    PubMed 

    Google Scholar 

  • Hendriks S, Ranson JM, Peetoom K, Lourida I, Tai XY, de Vugt M, et al. Risk factors for young-onset dementia in the UK Biobank. JAMA Neurol. 2024;81(2):134–42.

    PubMed 

    Google Scholar 

  • Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–46.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Deckers K, van Boxtel MP, Schiepers OJ, de Vugt M, Munoz Sanchez JL, Anstey KJ, et al. Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies. Int J Geriatr Psychiatry. 2015;30(3):234–46.

    PubMed 

    Google Scholar 

  • North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–108.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhao K, Chen P, Alexander-Bloch A, Wei Y, Dyrba M, Yang F, et al. A neuroimaging biomarker for Individual Brain-Related Abnormalities In Neurodegeneration (IBRAIN): a cross-sectional study. EClinicalMedicine. 2023;65:102276.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Tun X, Wang EJ, Gao Z, Lundberg K, Xu R, Hu D. Integrin beta3-mediated cell senescence associates with gut inflammation and intestinal degeneration in models of Alzheimer’s disease. Int J Mol Sci. 2023;24(6).

  • Rommer PS, Bsteh G, Zrzavy T, Hoeftberger R, Berger T. Immunosenescence in neurological diseases-is there enough evidence? Biomedicines. 2022;10(11).

  • Yang T, Xiao Y, Cheng Y, Huang J, Wei Q, Li C, et al. Epigenetic clocks in neurodegenerative diseases: a systematic review. J Neurol Neurosurg Psychiatry. 2023;94(12):1064–70.

    PubMed 

    Google Scholar 

  • Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study. PLoS Med. 2018;15(12):e1002718.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Gao X, Geng T, Jiang M, Huang N, Zheng Y, Belsky DW, et al. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. Nat Commun. 2023;14(1):2277.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhou A, Wu Z, Zaw Phyo AZ, Torres D, Vishwanath S, Ryan J. Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review. Epigenomics. 2022;14(18):1125–38.

    CAS 
    PubMed 

    Google Scholar 

  • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science. 1993;261(5123):921–3.

    CAS 
    PubMed 

    Google Scholar 

  • Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673–734.

    PubMed 

    Google Scholar 

  • Ebenau JL, van der Lee SJ, Hulsman M, Tesi N, Jansen IE, Verberk IMW, et al. Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score. Alzheimers Dement (Amst). 2021;13(1):e12229.

    PubMed 

    Google Scholar 

  • Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLos Med. 2015;12(3):10.

    Google Scholar 

  • Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging-US. 2018;10(4):573–91.

    Google Scholar 

  • Liu Z, Kuo P-L, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study. PLos Med. 2018;15(12):e1002718.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Rasmussen KL, Tybjærg-Hansen A, Nordestgaard BG, Frikke-Schmidt R. APOE and dementia – resequencing and genotyping in 105,597 individuals. Alzheimers Dement. 2020;16(12):1624–37.

    PubMed 

    Google Scholar 

  • Ma H, Li X, Zhou T, Wang MY, Heianza Y, Qi L. Long-term exposure to low-level air pollution, genetic susceptibility and risk of dementia. Int J Epidemiol. 2023;52(3):738–48.

    PubMed 

    Google Scholar 

  • Littlejohns TJ, Collister JA, Liu XN, Clifton L, Tapela NM, Hunter DJ. Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia. Alzheimers Dement. 2023;19(2):467–76.

    CAS 
    PubMed 

    Google Scholar 

  • Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genet. 2019;51(3):414-+.

    CAS 
    PubMed 

    Google Scholar 

  • Ebenau JL, van der Lee SJ, Hulsman M, Tesi N, Jansen IE, Verberk IMW, et al. Risk of dementia in APOE epsilon4 carriers is mitigated by a polygenic risk score. Alzheimer’s & dementia (Amsterdam, Netherlands). 2021;13(1):e12229.

    Google Scholar 

  • Wilkinson T, Ly A, Schnier C, Rannikmae K, Bush K, Brayne C, et al. Identifying dementia cases with routinely collected health data: A systematic review. Alzheimers Dement. 2018;14(8):1038–51.

    PubMed 

    Google Scholar 

  • van der Flier WM, Pijnenburg YAL, Fox NC, Scheltens P. Early-onset versus late-onset Alzheimer’s disease: the case of the missing APOE ε4 allele. Lancet Neurol. 2011;10(3):280–8.

    PubMed 

    Google Scholar 

  • Seath P, Macedo-Orrego LE, Velayudhan L. Clinical characteristics of early-onset versus late-onset Alzheimer’s disease: a systematic review and meta-analysis. Int Psychogeriatr. 2023:17.

  • Sabbagh MN, Perez A, Holland TM, Boustani M, Peabody SR, Yaffe K, et al. Primary prevention recommendations to reduce the risk of cognitive decline. Alzheimers Dement. 2022;18(8):1569–79.

    PubMed 

    Google Scholar 

  • WHO Guidelines Approved by the Guidelines Review Committee. Risk reduction of cognitive decline and dementia: WHO Guidelines. Geneva: World Health Organization. © World Health Organization 2019.; 2019.

  • Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Kuzma E, et al. Association of lifestyle and genetic risk with incidence of dementia. JAMA-J Am Med Assoc. 2019;322(5):430–7.

    Google Scholar 

  • Shen C, Rolls ET, Cheng W, Kang JJ, Dong GY, Xie C, et al. Associations of social isolation and loneliness with later dementia. Neurology. 2022;99(2):E164–75.

    PubMed 

    Google Scholar 

  • Ma LZ, Zhang YR, Li YZ, Ou YN, Yang L, Chen SD, et al. Cataract, cataract surgery, and risk of incident dementia: a prospective cohort study of 300,823 participants. Biol Psychiatry. 2023;93(1):810–9.

    PubMed 

    Google Scholar 

  • Gentreau M, Rukh G, Miguet M, Clemensson LE, Alsehli AM, Titova OE, et al. The effects of statins on cognitive performance are mediated by low-density lipoprotein, C-reactive protein, and blood glucose concentrations. J Gerontol Ser A-Biol Sci Med Sci. 2023;78(11):1964–72.

    CAS 

    Google Scholar 

  • Kung CSJ, Pudney SE, Shields MA. Economic gradients in loneliness, social isolation and social support: evidence from the UK Biobank. Soc Sci Med. 2022;306:14.

    Google Scholar 

  • Wang JL, Gao YY, Lin YJ, Sun XM, Ye SZ, Shi Y, et al. Interactive effects of air pollutants and temperature on incidence of dementia: a prospective cohort study. Environ Res Lett. 2023;18(7):15.

    Google Scholar 

  • Camargo KR Jr, Ortega F, Coeli CM. Modern epidemiology and its discontents. Rev Saude Publica. 2013;47(5):984–91.

    PubMed 

    Google Scholar 

  • Jylhava J, Pedersen NL, Hagg S. Biological age predictors EBioMedicine. 2017;21:29–36.

    PubMed 

    Google Scholar 

  • Putter H, Fiocco M, Geskus RB. Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 2007;26(11):2389–430.

    CAS 
    PubMed 

    Google Scholar 

  • Wang T, Duan WW, Jia XY, Huang XM, Liu Y, Meng FQ, et al. Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study. Eur Resp J. 2024;63(2):13.

    Google Scholar 

  • Sugden K, Caspi A, Elliott ML, Bourassa KJ, Chamarti K, Corcoran DL, et al. Association of pace of aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia. Neurology. 2022;99(13):e1402–13.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Starnawska A, Tan Q, Lenart A, McGue M, Mors O, Børglum AD, et al. Blood DNA methylation age is not associated with cognitive functioning in middle-aged monozygotic twins. Neurobiol Aging. 2017;50:60–3.

    CAS 
    PubMed 

    Google Scholar 

  • Sibbett RA, Altschul DM, Marioni RE, Deary IJ, Starr JM, Russ TC. DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921. BMC Psychiatry. 2020;20(1):91.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Shadyab AH, McEvoy LK, Horvath S, Whitsel EA, Rapp SR, Espeland MA, et al. Association of epigenetic age acceleration with incident mild cognitive impairment and dementia among older women. J Gerontol A Biol Sci Med Sci. 2022;77(6):1239–44.

    CAS 
    PubMed 

    Google Scholar 

  • Marioni RE, Suderman M, Chen BH, Horvath S, Bandinelli S, Morris T, et al. Tracking the epigenetic clock across the human life course: a meta-analysis of longitudinal cohort data. J Gerontol A Biol Sci Med Sci. 2019;74(1):57–61.

    PubMed 

    Google Scholar 

  • Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573–91.

    PubMed 

    Google Scholar 

  • Hjelmborg JB, Dalgard C, Moller S, Steenstrup T, Kimura M, Christensen K, et al. The heritability of leucocyte telomere length dynamics. J Med Genet. 2015;52(5):297–302.

    CAS 
    PubMed 

    Google Scholar 

  • Mason A, Holmes C, Edwards CJ. Inflammation and dementia: using rheumatoid arthritis as a model to develop treatments? Autoimmun Rev. 2018;17(9):919–25.

    CAS 
    PubMed 

    Google Scholar 

  • Arjunan A, Song J. Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia. Biomed Pharmacother. 2023;163:114847.

    CAS 
    PubMed 

    Google Scholar 

  • Faridar A, Thome AD, Zhao W, Thonhoff JR, Beers DR, Pascual B, et al. Restoring regulatory T-cell dysfunction in Alzheimer’s disease through ex vivo expansion. Brain Commun. 2020;2(2):fcaa112.

  • Andrews SJ, Fulton-Howard B, Goate A. Interpretation of risk loci from genome-wide association studies of Alzheimer’s disease. Lancet Neurol. 2020;19(4):326–35.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen L, Wu B, Mo L, Chen H, Zhao Y, Tan T, et al. Associations between biological ageing and the risk of, genetic susceptibility to, and life expectancy associated with rheumatoid arthritis: a secondary analysis of two observational studies. Lancet Healthy Longev. 2024;5(1):e45–55.

    PubMed 

    Google Scholar 

  • Wang T, Duan W, Jia X, Huang X, Liu Y, Meng F, et al. Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study. Eur Respir J. 2024;63(2).

  • Saddiki H, Fayosse A, Cognat E, Sabia S, Engelborghs S, Wallon D, et al. Age and the association between apolipoprotein E genotype and Alzheimer disease: a cerebrospinal fluid biomarker-based case-control study. PLoS Med. 2020;17(8):e1003289.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 2009;5(8):e1000602.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kuo CL, Pilling LC, Liu Z, Atkins JL, Levine ME. Genetic associations for two biological age measures point to distinct aging phenotypes. Aging Cell. 2021;20(6):e13376.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar