Emulate, Inc. introduces the Rigid Chip-R1™ chip with a minimal drug absorbing profile to improve biological modeling for ADME and toxicology applications

Emulate, Inc., the leader in the next generation in vitro Organ-Chip Models today announced the release of its new Chip-R1™ Rigid Chip, designed to minimize drug absorption and improve biological modeling. Chip-R1 is made of low drug absorption plastics and builds on the microfluidic core design of organ chips, providing researchers with greater precision in predicting human drug responses.

Chip-R1's new features not only increase the accuracy of organ chip experiments for ADME and toxicology applications, but can also improve research in many other areas. The modified design of the vascular channel enables physiologically relevant shear stresses, which are crucial for vascular biology applications such as the recruitment of immune cells. Additionally, this model features a thinner membrane with smaller pores, allowing for increased cellular crosstalk and better approaches to the membrane in vivo Milieu.

New features of Chip-R1 include:

• Minimally absorbent chip materials for accurate drug testing
• Better approach to the in vivo Microenvironment caused by increased shear stress in the vascular canal
• A pre-activated tissue culture membrane to simplify the user's workflow
• Reduced imaging distance, greater compatibility for microscopy

“This represents a major advance in Emulate’s organ-on-a-chip technology and allows customers to test compounds that were previously unaddressable,” said Danny Levner, PhD, chief technology officer at Emulate. “With its low drug absorption properties, Chip-R1 is well suited for drug development applications such as pharmacokinetics and pharmacodynamics, where consistent and predictable drug exposure is critical.”

Chip-R1 retains much of the same microfluidic architecture as the Chip-S1® Stretchable Chip, including co-culture to model the tissue-tissue interface, independent perfusion of the apical and basal channels, and compatibility with Emulate's instrumentation hardware. With a new polycarbonate tissue culture membrane, Chip-R1 is more suitable for organ models that do not require mechanical stretching to mimic physiological functions such as peristalsis, such as: B. Liver and kidney.

“Chip-R1 shows the continuous development of our innovative consumables portfolio. With improved detection of hepatotoxicity compared to Chip-S1, it expands the use of organ chips to scientists previously concerned about how potential drug absorption impacts the accuracy of detecting drug-induced toxicity of small molecule lipophilic drugs,” said Lorna Ewart, PhD, Chief Scientific Officer at Emulate.