Houston vs. TCU odds, line, spread: 2024 college football picks, Week 6 predictions using a proven model

State rivals TCU and Houston meet on Friday evening in one of the more recent Big 12 duels. Houston joined the conference just last season, but has gone just 2-9 in Big 12 play since then, including 0-2 this season. The Cougars have a 1-4 overall record in 2024, while TCU is 3-2 overall and 1-1 in conference play. The Horned Frogs prevailed in their first Big 12 matchup a year ago, defeating the Cougars in nine straight meetings. TCU is 1-4 against the spread this season while Houston is 2-3 ATS.

Kickoff will take place at 7:30 p.m. ET at Amon G. Carter Stadium in Fort Worth, Texas. After opening at -18.5, the Horned Frogs are now up by 16.5 points in the latest TCU vs. Houston odds, while the over/under is at 51, according to the SportsLine consensus. Before entering any Houston vs. TCU picks, here's what you should do: See the college football predictions from the advanced computer model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, its top-rated college football picks against the spread have generated well over $2,000 in profits for $100 players. Plus, all top college football picks went a sizzling 6-0 in Week 5. Everyone who has followed it has seen strong results.

The model has TCU vs. Houston in its sights. You can head over to SportsLine to check out the picks. Here are several college football betting lines for spread, money line, and over/under:

• TCU vs. Houston Spread: TCU -16.5
• TCU vs. Houston over/under: 51 points
• Moneyline TCU vs. Houston: TCU -820, Houston +548
• TCU vs. Houston Picks: Check out the picks here
• TCU vs. Houston Streaming: FuboTV (Try Free)

Why Houston can cover

The Cougars have the defensive ability to slow down TCU and make this game a competitive one, as only 10 teams in all of college football allow fewer passing yards per game than Houston. If TCU can't move the ball through the air, its offense could grind to a halt as the Horned Frogs simply aren't built to run the ball. Their 101 rushing yards per game ranks 115th out of 134 FBS teams, and their minuscule 3.3 yards per carry also ranks 115th nationally.

Houston also has significant advantages in terms of spread success. After a straight loss since the start of last year, the team is 6-3, while TCU typically doesn't do well with success in the following game. The Horned Frogs are just 2-5 ATS after one win since the start of 2023. That represents just a 28.6% coverage rate and is the second-worst coverage rate among current Big 12 teams. See which team you should choose here.

Why TCU can cover

Few teams can match the offensive productivity of the Horned Frogs, who rank third in the Big 12 in scoring and fourth in all of college football in passing attack. TCU had three passing touchdowns in its win over Kansas last week, matching the number of passing TDs Houston has had this entire season. Quarterback Josh Hoover leads the Big 12 in both total yards (1,768) and total touchdowns (16) and has an elite option in the outfield in Jack Bech.

After two years at LSU, Bech transferred to TCU last year, but 2024 was his breakout season. He ranks second in the FBS in receiving yards (647) and third in receiving TDs (six), while leading the Big 12 in both categories. He has recorded at least eight receptions and 131 yards in each of his last three games, while scoring five total touchdowns. He also has a solid running mate in Eric McAlister, who himself has two consecutive 100-yard receiving games. See which team you should choose here.

How to make Houston vs. TCU picks

The model has simulated TCU vs. Houston 10,000 times and the results are in. The model leans over and has also generated a point spread pick that hits in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Houston vs. TCU and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the TCU vs. Houston spread you should jump on, all from the advanced computer model that has risen well over $2,000 compared to its top-rated college football spread picks since its inception is, and find out.